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There are a couple of different options to choose from when shopping for the best bed bug sprays.

A can of EcoLogic Safe Aerosol Bed Bug Killer on a yellow textured background

The Spruce

These formulas work through preventing energy production and dehydration.

The spray even kills pyrethroid-resistant bed bugs, helping to control the toughest of infestations.

While its not made with natural ingredients, the quick-acting ingredients in this spray ultimately make it highly effective.

MGK Bedlam Plus Fast-Acting Bed Bug Spray

PHOTO: Amazon

Plus, the natural active ingredientsprimarily lemongrass and cornmint oildont limit the effectiveness.

The spray kills bed bugs on contact, including pyrethroid-resistant bugs and eggs.

Of course, we also like that the spray is eco-friendly.

EcoLogic Safe Aerosol Bed Bug Killer

PHOTO: The Home Depot

One note is that there is no residual effectiveness listed.

We like that the natural insecticide is made by a team of entomologistspeople who study insects for a living.

The formula eliminates bugs and their eggs, making treatment fast and effective.

Premo Guard Bed Bug Killer Spray

PHOTO: Amazon

The organic citric acid active ingredient is also safe for pets and kids.

We love that the formula is effective against adult bed bugs, as well as eggs and pyrethroid-resistant bugs.

This aerosol version is fast-acting, though you might also choose from larger sprays if you need more quantity.

Harris Toughest Bed Bug Killer

PHOTO: Amazon

Think: Small openings between floorboards and finicky crevices and cracks along your baseboards.

The spray is also non-staining, so it can be used on water-safe upholstery.

Theres also a sliding trigger lock, which prevents leaks and acts as a safety feature.

Raid Bed Bug Foaming Spray

PHOTO: Amazon

Speaking of which, the formula is safe for use around kids and pets after it fully dries.

The gallon size is perfect for use in multiple roomsand still rings in at a reasonable price.

We love that it kills bugs at all stages, from eggs to adults.

Ortho Home Defense Max Bed Bug Killer

PHOTO: Amazon

It also targets fleas and dust mites as a bonus.

Once applied, keep your pets and children away from the spray until it dries.

Its effective against bed bugs at all life stages.

Hot Shot Ready-to-Use Bed Bug Killer Spray

PHOTO: Amazon

Just note that it is not listed as being effective against pyrethroid-resistant bugs or having residual effectiveness.

It is a water-based formula that is non-staining and eliminates bugs at all life stages.

Contact sprays and residual sprays primarily differ in how quickly they take effect.

Eco Defense Bed Bug Spray Travel Size

PHOTO: Amazon

Although this method takes time, residual sprays can offer prolonged effectiveness against these insects.

Ingredients MatterBut It Depends on Your Infestation

Certain ingredients are commonly used in mostinsect sprays and repellents.

For contact sprays, pyrethroids and pyrethrins are fast-acting as they target bed bugs nervous systemsoptimal for active infestations.

Meanwhile, residual insecticides like chlorfenapyr inhibit energy production.

Some sprays also contain insect growth regulators which prevent reproduction and the maturity of bedbugs.

This can help with long-term prevention.

These sprays often contain methoprene and pyriproxyfen, Bossel notes.

Consider the system Approach and Location

Different spray formulas will also be best for different use cases.

This will prevent stains on your furniture.

Plus, these pesticide-free sprays are typically odorless, so they won’t leave a persistent smell.

Some formulas can better target hard-to-reach areas.

Why Trust The Spruce?

This roundup was written byShagun Khare, a home writer who has been writing for The Spruce since 2021.